Nerve growth factor employs multiple pathways to induce primary response genes in PC12 cells.
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منابع مشابه
Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor
PC12 cells, which differentiate morphologically and biochemically into sympathetic neruonlike cells in response to nerve growth fact, also respond to epidermal growth factor. The response to epidermal growth factor is similar in certain respects to the response to nerve growth fact. Both peptides produce rapid increases in cellular adhesion and 2-deoxyglucose uptake and both induce ornithine de...
متن کاملRapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor
The effect of nerve growth factor (NGF), a substance that promotes the differentiation and maintenance of certain neurons, was studied via scanning electron microscopy utilizing the PC12 clonal NGF-responsive pheochromocytoma cell line. After 2-4 d of exposure to NGF, these cells acquire many of the properties of normal sympathic neurons. However, by phase microscopy, no changes are discernible...
متن کاملNerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells.
Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation and apoptosis; however, the signals responsible for this regulation have not been identified. We use here the clusterin gene as a model system to examine expression i...
متن کاملEffect of nerve growth factor and fibroblast growth factor on PC12 cells: inhibition by orthovanadate
Sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, causes increased levels of tyrosine phosphorylation and blocks, at noncytotoxic concentrations, the differentiative response of rat pheochromocytoma (PC12) cells to beta-nerve growth factor (beta NGF) and basic fibroblast growth factor (bFGF) in a reversible manner. It also prevents growth factor-induced neurite proliferation ...
متن کاملNerve growth factor-induced increase in saxitoxin binding to rat PC12 pheochromocytoma cells.
The PC12 clone is a line of rat pheochromocytoma cells which undergoes neuronal differentiation in the presence of nerve growth factor (NGF) protein. In the absence of NGF, PC12 cells are electrically inexcitable, while after several weeks of NGF treatment, they develop sodium action potentials. The number and density of sodium channels on PC12 cells before and after treatment with NGF were est...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1992
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.3.3.363